RNA Interference in Fungi: Pathways, Functions, and Applications

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RNA interference pathways in fungi: mechanisms and functions.

RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses small noncoding RNAs to mediate posttranscriptional/transcriptional gene silencing. The fission yeast Schizosaccharomyces pombe and the filamentous fungus Neurospora crassa have served as important model systems for RNAi research. Studies on these two organisms and other fungi have contributed significantly to...

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RNA silencing in fungi: mechanisms and applications.

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Loss and Retention of RNA Interference in Fungi and Parasites

RNA interference (RNAi) or RNA silencing is a gene regulatory system, widely conserved in eukaryotes, that represses gene expression through a homology-dependent mechanism. This repressive effect is mediated by small non-coding RNAs (sRNAs) of about 20–30 nucleotides, derived from double-stranded RNA (dsRNA) precursors that are recognized and processed by the RNaseIII Dicer. These sRNAs are loa...

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ژورنال

عنوان ژورنال: Eukaryotic Cell

سال: 2011

ISSN: 1535-9778,1535-9786

DOI: 10.1128/ec.05109-11